文档介绍：Leukemia (白血病)
谢毅(Xie yi)
,Huashan Hospital
2017/11/11
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xie Yi,Hua Shan Hospital
Concept of leukemia
Definition
It is the results of the tumor proliferation of heamotopoietic stem cells.(造血干细胞)
Leukemia is a malignant blood disorder. (not solid tumor)
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xie Yi,Hua Shan Hospital
Heamatopoietic stem cell
reproduction HSC
lymphoid HSC
HSC
differentiation early progenitor
CFU-GEMM
myeloid HSC
Heamatopoietic Stem Cell (HSC) is the primary cell of Heamatopoietic system and immune system.
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xie Yi,Hua Shan Hospital
Tumor proliferation of HSC
Differentiation of HSC is blocked.
Leukemia cells are stopped on a differentiation stage of HSC & lack of the normal function .
Proliferation is out of control and apoptosis is inhibited.
Leukemia cell is cloned and accumulated in a great quantity.
infiltration and metastasis
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xie Yi,Hua Shan Hospital
malignant blood disorders
HSC differentiation is blocked.
Normal blood cells are decreased and leukemia cell is increased.
The function of Blood and immune system are short of.
Fever ,bleeding ,anemia
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xie Yi,Hua Shan Hospital
malignant blood disorders
Proliferation is out of control ,apoptosis is inhibited and leukemia cell is accumulated in a great quantity.
Leukostasis(白细胞淤滞)
Abnormal morphology pictures of blood and bone marrow
Liver,spleen,lymph nods, S are infiltrated and dysfunctional frequently.
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xie Yi,Hua Shan Hospital
According to the acute myeloid leukemia(AML)
Differentiation & M0 M1 M2 ……………….. M7
Kind of cell blast crisis of CML,mast cell leukemia,
acute eosinophilic leukemia,basophilic…………
leukemia acute lymphocyte leukemia(ALL)
L1,L2,L3
T-ALL、B-ALL
chronic leukemia: CML、P-LL、CLL、HCL、……
leukemia
the tradition classification (FAB)of leukemia
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WHO classification (2001)
1, Acute myeloid leukemia(AML)
(1), AML with recurr