文档介绍：Iron-Deficiency Anemia Zhongshan Hospital ,Fudan University Zou Shanhua
Definition
Absent iron-store
hemoglobin synthesis↓
A microcytic and hypochromic anemia
The mon nutritional anemia
Iron metabolism : Iron source and absorption
iron:
hemoglobin stomach acid,prolease heme heme oxygenase
protoporphyrin
iron
Its absorption is not influenced by food ingrediant
Iron source and absorption
iron:
Fe3+→stomach acid,VitC →Fe2+
:10-15mg/d;10% absorbed
portions:duodenum and upper part of
jejunum
5. Absorption rate
Iron transportation
Fe2+ → Fe3+ → ferritin
Fe3+→transferrin→receptor (erythroblast)
→ mitochondria protoporphyrin heme
ferritin
Total iron-binding capacity(TIBC)
Serum iron (SI)
Transferrin saturation :SI/TIBC×100%=33%~35%
Tansferrin receptor
Iron distribution and storage
Normal iron content Male:50mg/kg weight
Female:35mg/kg weight
Iron distribution % --- hemoglobin
% --- myoglobin
% --- ferritin and hemosiderin
< 1% --- enzymes , transferrin and
ferritin in blood plasma
Form of storage:ferritin and hemosiderin
Iron recycle and excretion
Recycle
Excretion
-
epithelial cell of intestinal tract
bile
urinary tract
skin
sweating
Etiology and mechanism
rapid growing infants, adolacent
relative
Insufficient pregnant and lactating female
uptake inadequate nutrition ,dietary bias
absolute postgastrectomy
anacidity
frequent vomit
chronic diarrhea
Etiology and mechanism
digestion tract hemorrhage:peptic ulcer ,cancer,
Overabundance ancylostomiasis ,varices,
Loss acute gastritis,hemorrhoids
( hemorrhage ) recurrent rhinorrhagia
excessive menses
Clinical manifestations
Oxygen deficiency ans:
symptom:dizzy,fatige,palpitation,short of breath,tinnitus
physical finding: paleness,
ankle edema
cardiac murmur