文档介绍：氨基葡萄糖在骨性关节炎诊疗中的应用:盐酸氨基葡萄糖胶囊
摘 要 骨性关节炎是一个常见的慢性关节疾病，诊疗方法种类繁多，但尚缺乏理想的药品来逆转疾病的进程。氨基葡萄糖由结合氨基的单糖、黏多糖和壳多糖组成，是参加关节内多个分子的结构组成。近10多年来，氨基葡萄糖已广泛用于临床诊疗骨性关节炎。本文就氨基葡萄糖的药动学、药理作用和临床应用作一综述。
关键词 骨性关节炎 氨基葡萄糖 药动学 药理学 临床应用
中图分类号： 文件标识码：A 文章编号：1006-153315-0008-04
Application of glucosamine in management of osteoarthritis
WU Zi-ying, Li Yun-xia, CHEN Shi-yi
(Sports Medicine Center, Department of Sports Medicine and Arthroscopy Surgery
of Huashan Hospital, Fudan University, Shanghai 202140, China
Abstract Osteoarthritis is a common, chronic arthritis disease. Despite of being many measurements for its treatment, modifying-osteoarthritis medicine has not come into being for reversing the disease process. Glucosamine is composed of amino-bound monosaccharide, mucopolysaccharide and chitin participates in forming the structures of several articular moleculars in joints. During recent ten years, glucosamine has been widely applied to treat osteoarthritis. This review discusses the pharmacokinetics, pharmacologic effects and clinical application of glucosamine.
Key words osteoarthritis; glucosamine; pharmacokinetics; pharmacology; clinical application
骨性关节炎是一个慢性关节疾病，关键病变是关节软骨的退行性变和继发性骨质增生，按致病原因可分为原发性和继发性骨性关节炎。该病可发生于各年纪段、尤以老年人中最为多见。伴随中国老龄人口的增加，发病人数逐年上升。骨性关节炎常可造成患者关节疼痛及其功效障碍、甚至所以残疾，而使用非甾体抗炎药等传统药品诊疗关键是对症处理，无法逆转疾病的发生和发展。但即便NSAID的有效性受到质疑且会带来诸如消化道溃疡、出血和肾衰竭等并发症，因为还未开发出理想的药品，NSA