文档介绍：[CANCER RESEARCH 64, 8309–8317, November 15, 2004] P-Cadherin Is Up-Regulated by the Antiestrogen ICI 182,780 and Promotes Invasion of Human Breast Cancer Cells Joana Paredes, 1Christophe Stove, 3,5 Veronique Stove, 4Fernanda Milanezi, 1Veerle Van Marck, 3Lara Derycke, 3 Marc Mareel, 3Marc Bracke, 3and Fernando Schmitt 1,2 1Institute of Pathology and Molecular Immunology of Porto University and 2Medical Faculty, Porto University, Porto, Portugal; and 3Laboratory of Experimental Cancerology, Department of Radiotherapy and Nuclear Medicine, 4Department of Clinical Chemistry, Microbiology and Immunology, Ghent University Hospital, and 5Units of Molecular and Cellular Oncology and Molecular Cell Biology, Department of Molecular Biomedical Research, VIB-Ghent University, Ghent, Belgium ABSTRACT P-cadherin expression in breast carcinomas has been associated with tumors of high histologic grade and lacking estrogen receptor- ?, suggest- ing a link between these proteins. In the MCF-7/AZ breast cancer cell line, blocking estrogen receptor- ?signaling with the antiestrogen ICI 182,780 induced an increase of P-cadherin, which coincided with induction of in vitro invasion. Retroviral transduction of MCF-7/AZ cells, as well as HEK 293T cells, showed the proinvasive activity of P-cadherin, which requires the juxtamembrane domain of its cytoplasmic tail. This study establishes a direct link