文档介绍：中华临床医师杂志(电子版)2014 年 3 月第 8 卷第 6 期 Chin J Clinicians(Electronic Edition),March 15,2014,, ·1155·
·综述·
骨髓增生异常综合征患者 T 淋巴细胞亚群的变化
刘菲张连生李莉娟
【摘要】骨髓增生异常综合征(MDS)的发病机制主要是造血干细胞或恶性克隆细胞获得生
长优势而异常增殖,正常造血克隆受到抑制或过度凋亡,最终导致了外周血细胞减少,进而向白血
病转化。细胞免疫紊乱在MDS的发病中尤为重要,正确深入地了解MDS的免疫调节机制对其治疗有
重要的指导意义,本文旨在针对MDS患者的T淋巴细胞亚群数量、比例及免疫功能失调等现象进行
综述。
【关键词】骨髓增生异常综合征; T淋巴细胞亚群; 免疫,细胞
Changes of T lymphocyte subsets in myelodysplastic syndrome patients Liu Fei, Zhang Liansheng, Li
Lijuan. Department of Hematology, Lanzhou University Second Hospital, Lanzhou 730030, China
Corresponding author: Zhang Liansheng, Email: zls2170@
【Abstract】 The pathogenesis model of myelodysplastic syndrome (MDS) is hematopoietic
stem/progenitor cells or malignant clone cells growth advantage and excessive proliferation and normal
hematopoiesis cloning is restrained or excessive apoptosis, leading to decreased peripheral blood cells and
to leukemic transformation. Cellular immune disorder is particularly important in the pathogenesis of MDS.
The correctly and deeply understanding of the MDS immune regulation mechanism has important guiding
significance for its treatment. In this paper, the T lymphocyte subsets of MDS patients quantity, scale,
immune dysfunction and other phenomena were summarized.
【Key words】 Myelodysplastic syndromes; T-lymphocyte subsets; Immunity, cellular
5骨髓增生异常综合征(