文档介绍：小儿葫芦散对大鼠毒性的实验研究
【摘要】目的：观察小儿葫芦散对大鼠的毒性反应，对小儿葫芦 散作临床安全性再评价。方法：选用Wister大鼠为受试动物，观察小 儿葫芦散以生药3 g/kg. 6 g/kg的剂量1次/d给药，连续4 w以观 察其毒性反应。结果：给药期间动物的一般情况、体重与生理盐水组 比较无显著性差异。实验4 w及恢复期血常规和血液生化指标给药组 与对照组比较无显著性差异(P>O. 05)o动物尸检各主要脏器未见 明显病理改变，对照组动物脏器系数和各给药组相比无明显差异，且 均在正常范围，各器官组织未见病理学改变。结论：小儿葫芦散连续 4 w给大鼠灌胃给药未出现任何毒性反应。
【关键词】小儿葫芦散；大鼠；毒性；实验研究
Experimental Study of Toxicity of Xiaoer Hulu Powder on Wister Rats
Bai Yao, Piao Jinhua
(Shanxi College of TCM, Taiyuan Shanxi 030024)
Abstract Objective:To observe the toxicity of Xiaoer Hulu powder on Wister rats. Method: 72 Wister rats were randomly divided into normal group, Xiaoer Hulu powder group 1 (3 g/kg), group 2 (6 g/kg) . Xiaoer Hulu powder group 1 and group 2 were given Xiaoer Hulu powder by stomach perfusing respectively once a day for four weeks. Then body weighs, hematological indexes, biochemical indexes of the blood and pathological changes of rats were observed. Result
: The diffrerence of body weighs, hematological indexes, biochemical indexes of the blood, pathological changes and organ coefficients were not obvious between Xiaoer Hulu powder groups and normal group. Conclusion: Xiaoer Hulu powder had no toxicity on Wister rats.
Key words Xiaoer Hulu powder; rats; toxicity: experimental study小儿葫芦散是由橘红、茯苓、朱砂、鸡内金(炒)、天麻等中药 组成的复方制剂。为了确保小儿葫芦散的临床用药安全性，在此我们 对其毒性进行再评价。由于本品难以测出半数致死量(LD50),故选用 大鼠为受试动物，观察本品连续4 w给大鼠灌胃所产生的毒性反应、 首发症状和严重程度、毒性反应