文档介绍：腔隙性脑梗塞与胰岛素抵抗关系的探讨
作者:王淼霞，胡治平,周文胜
作者单位：1湖南省马王堆医院，湖南长沙市410016;2 中南 大学湘雅第二医院神经内科
【摘要】 目的：探讨腔隙性脑梗塞(CLI)患者是否存在胰 岛素抵抗的问题。方法：测定35例CLI患者与35例健康对照者的血 清空腹葡萄糖，空腹胰岛素，血脂(甘油三酯和低密度脂蛋白-胆固醇), 并计算胰岛素敏感性指数。结果：CLI组胰岛素敏感性指数低于正常 对照组(P<0 01),而空腹血糖、胰岛素、血脂浓度高于对照组(P<0
01-0 05)o结论：腔隙性脑梗塞患者存在胰岛素抵抗，胰岛素
抵抗可能是腔隙性脑梗塞的危险因素之一。
【关键词】 脑梗塞胰岛素血糖
Explore of correlation between cerebral lacunal infarction and insulin resistanceAVANG Miaolxia,HU Zhilping,ZHOU Wenlsheng,DENG Jinglgui,SONG Tao//Chinese Journal of Cardiovascular Rehabilitation Medicine,2007,16(1):46
Abstract： Objective:To explore whether there is insulin resistance in patients with cerebral lacunal infarction(CLI).Methods:The fasting blood glucose(FBG),insulin,blood lipid (total cholesterol and triglyceride) were examined in 35 patients and 35 healthy controls and their insulin sensitivity index(ISI) were :The ISI of the
CLI group was significantly lower(P<0 01) than that in the control group while levels of FBG,insulin,blood lipid in CLI group increased(P<0
05-<0 01).Conclusion:There is insulin resistance in patients with cerebral lacunal insulin resistance may be one of its risk factors for cerebral lacunal infarction.
Author' s address： Department of Neurology,Mawangdui Hospital,Changsha,Hunan,410011,China
Key words： Cerebral infarction; Insulin;Blood glucose 胰岛素 抵抗(IR)是存在于多种疾病的一种共同的病理状态。目前国内外许 多研究认为I