文档介绍：Molecular association between diabetes-specific local
work and nutrient metabolism modules
Ting Zhang1†, Changlu Guo2†, Qingdai Liu1†, Zhizhou Zhang1,3*, Qian Wang 1, Changlu Wang1, Yadong Wang2
1Teda Bio-X Center for Systems Biotechnology, Tianjin University of Science and Technology, Tianjin, China 300457
2Research Center of Bioinformation Technology, School puter Science and Technology,
3Bio-X Center for Marine BioTechnology, Harbin Institute of Technology, Weihai, China 264209
†Equal contribution; *Corresponding: zhangzzbiox@
Abstract—Local work pattern (LGNP) is a useful tool to data, only 9 have known pathway information. Diabetes-
plex relationship between multiple genes. A diabetes- specific LGN could be associated with several nutrition
specific local work (LGN) was constructed with 29 genes metabolism modules. Thus, a way for diabetes-specific formula
(including 9 diabetes susceptibility genes and 20 extra genes to food therapy could be designed in future.
join them) that participate in 30 biological pathways. Further
analysis indicated diabetes-specific LGN has close relations with Moreover, scientists observed that obesity tends to induce
carbohydrate metabolism, lipid metabolism, amino acid diabetes; meanwhile, long-term consequences of diabetes are
metabolism, cofactor and vitamin metabolism. Especially, severe and may induce