文档介绍：Apop-1 Induces caspase-dependent Apoptosis
Xin Sun※1, Gang Lv1, Ling Gao1, Fanli Kong1, Xiaotao Zhu2, Dan Tian1, Haibin Tong1, Xiaodan Chu1,Yu Xie
1 Life Science Center, Beihua University China;
2 Department of Surgery, Central Hospital of Jilin, Jilin, China;
※Correspondence: Xin Sun E-mail: sxin1122@
Abstract There are two major pathways for the
Apoptosis is a form of ically induction of apoptosis. One is the extrinsic
programmed cell death, which plays a or receptor-mediated pathway represented
pivotal role in normal development and the by Fas and tumor necrosis factor receptor.
maintenance of homeostasis of a variety of The other is the intrinsic mitochondria
tissues including cardiovascular system. mediated pathway, in which mitochondria
Apop-1 is a soluble protein consisting of play a crucial role by releasing cytochrome
194 amino acids with a mitochondrial c from the inter-membrane space into the
localization signal at its N-terminus. cytoplasm5. Vascular smooth muscle cells
RT-PCR data revealed that Apop-1 is play a pivotal role in the development of
expressed in all ans tested. atherosclerosis6. These cells proliferate,
Immunofluorescence study showed that migrate, and produce extracellular matrix in
Apop-1 protein is localized in mitochondria. the atherosclerotic plaque formation.
Transient transfection experiment showed