文档介绍：Analysis of Module of Co-regulated Genes by
Integrating Information from Sequence and
Microarray
Qiang Bo, Wang Zheng-Zhi
College of Mechatronics Engineering and Automation
National University of Defense Technology
Changsha 410073, Hunan, China
Abstract— The researches of module of co-regulated genes act as represented in Fig. 1. In this situation, all the target genes have
important role in research of gene works. Present the same regulated pattern, that is, they are activated or
analysis of module of co-regulated genes generally have 2 repressed simultaneously, and are not regulated by other TF.
problems: The first one is that the co-expressed genes are
generally clustered as the co-regulated genes, but recent studies
show that only 50% genes are co-regulated when their Spearman
correlative coefficients are bigger than , so the co-regulated
genes need to be refined from cluster of co-expressed genes; the
other problem is that mon transcription factor (TF) is
usually unknown, this makes obstacle in quantitative analysis on
regulation relationships between TF and target genes. This paper
presents a method for analysis of module about co-regulated
genes by integrating information from sequences and microarray
data. Firstly we cluster the genes by the similarity of expression
profiles; then the co-regulated genes are refined