文档介绍：synthesis of water-soluble quaternized chitosans and
their antitumor activity
Fang Dong a,b,c Qinzhao Xue,a Jingli Liu,a,b,c ,
Jianming Rena,c, Zhanyong Guoa,*
aYantai Institute of Coastal Zone Research for Sustainable
Development,
CAS, Yantai, 264003, China
b
Institute of Oceanology, CAS, Qingdao, 266071, China
cGraduate School of the Chinese Academy of Sciences
Beijing, China
fdong03@
Abstract-water-soluble low-molecular-weight chitosan(LCTS) aldehydes, sodium iodide (NaI), sodium borohydride (NaBH4),
was prepared by hydrogen peroxide oxidation method and their and iodomethane (CH3I) were purchased from the Sigma–
quaternized derivatives(QLCTS) was also synthesized using Aldrich Chemical Co. The other reagents were all analytical
previous methods. Their antitumor activity was studied, and the grades and were used without further purification. The IR
results showed that the LMW and its quaternized derivatives spectra were measured on a Jasco-4100 FT-TR spectrometer
inhibited the growth of pancreatic carcinoma cell strain PANC-1 with KBr disks. The average etric molecular weight of
in vitro, and the inhibitory rate reached %. chitosan was estimated from the intrinsic viscosity determined
in the solvent CH3COOH/ NaCl using the Marke-
Keywords-water-souble; quaternized chitosan; antitumor ℃
activity Houwink parameter