文档介绍：摘要
吲哚美辛英文名为：Indomethacin。又名：抗炎吲哚酸，为非甾体抗炎药，具备抑制环氧酶作用致使前列腺素合成减少以达到抗炎、镇痛、解热作用。制止炎症组织痛觉神经冲动形成，抑制炎性反映。至于解热作用，由于作用于下视丘体温调节中枢，引起外周血管扩张及出汗，使散热增长。
综合考虑原料药来源，反映条件，反映收率，经济合理性中间产物污染性，目的产物纯度等各种条件，找到一条最佳反映路线，制定合理工业生产工艺流程。本文是以对甲氧基苯肼和乙醛为初始原料通过多步反映合成吲哚美辛，各步收率在80％以上。
本设计为年产50吨吲哚美辛生产车间工艺设计，重要涉及产品最佳合成路线、工艺流程设计及工艺流程图、生产过程物料衡算、厂区平面设计图、车间设备布置图、重要设备图等绘制，最后是毕业设计阐明书。
核心词：吲哚美辛抗炎镇痛合成办法工艺流程
Abstract
Indomethacin English name：Indomethacin. Also known as：Anti-inflammatory indole acid，non-steroidal anti-inflammatory drugs inhibit cyclooxygenase role in causing decreased prostaglandin synthesis in order to achieve anti-inflammatory，analgesic and antipyretic effects. Suppression of inflammatory tissue pain nerve impulses，inhibit the inflammatory response. As for the antipyretic effect，because acting on the hypothalamus thermoregulatory center，causing peripheral vasodilatation and sweating，heat dissipation increases..
Considering the source of drug substances，the reaction conditions，the reaction yield，economic rationality intermediate pollution，and the target product purity and many other conditions，to find an optimum reaction route to develop a reasonable industrial production process. This article is based on methoxyphenylhydrazine and acetaldehyde as starting materials through multi-step reaction of indomethacin，each step yields above 80%.
The design for the annual production capacity of 50 tons of indomethacin production plant process design，including the products of the best synthetic route，process design and process flow diagrams，process material balance，graphic design factory，workshop equipment layout maps，diagrams and other major equipment drawing，and finally graduated from the design specification.
Keywords： Indomethacin； Anti-inflammatory analgesic； Synthesis；Process
第一章概论
非甾体抗炎药（Nonsteroidal Antiinflammatory Drugs，NSAIDs）是一类不具有甾体构造抗炎药，NSAIDs自阿司匹林于1898年初次合成后，100近年来已有百余种上千个品牌上市。该类药物具备抗炎、抗风湿、止痛、退热和抗凝血等作用，在临床上广泛用于骨关节炎、类