文档介绍：Product Data Sheet Inhibitors
Liraglutide ---
10 mM --- --- ---
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品
失效。储备液的保存⽅式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个⽉内使
⽤，-20°C 储存时，请在 1 个⽉内使⽤。
BIOLOGICAL ACTIVITY
⽣物活性 Liraglutide 是⼀种胰⾼⾎糖素样肽-1 (GLP-1) 受体激动剂，⽤于治疗 2 型糖尿病。
IC₅₀ & Target GLP-1 receptor[1]
体外研究 Liraglutide binds to the same receptors as does the endogenous metabolic hormone GLP-1. Liraglutide is an
Page 1 of 2 drug for the treatment of type 2 diabetes, also can be used to treat obesity in adults with some related
comorbidity. Liraglutide activated AMPK/SREBP1 pathway in oxLDL-stimulated cells[1].
PROTOCOL
Cell Assay [1] macrophage cells are cultured in Dulbecco's modified Eagle's medium supplemented with 10% fetal bovine
serum in a humidified 37°C incubator with 5% CO2. The cells