文档介绍：Clinical Oncology (2009) 21: 401e407
doi:.
Original Article
Volumetric Modulated Arc Therapy and Conventional
Intensity-modulated Radiotherapy for Simultaneous Maximal
Intraprostatic Boost: a parison Study
R. Shaffer*y, W. J. Morris*, V. Moiseenko*, M. Welsh*, C. Crumley*, S. Nakano*,
M. Schmuland*, T. Pickles*, K. Otto*
*British Columbia Cancer Agency, 600 West 10th Avenue, Vancouver, British Columbia, Canada, V5Z 4E6; yImperial College
Healthcare NHS Trust, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, UK
ABSTRACT:
Aims: Volumetric modulated arc therapy (VMAT) is a novel extension of intensity-modulated radiotherapy (IMRT) where
an optimised three-dimensional dose distribution may be delivered in a single gantry rotation. This optimisation
algorithm is the predecessor to Varian’s RapidArc. The aim of this study was pare the ability of conventional static
nine-field IMRT (cIMRT) and VMAT to boost as much of the clinical target volume (CTV) as possible to Gy without
an at risk (OAR) dose-volume constraints.
Materials and methods: Optimal cIMRT and VMAT radiotherapy plans were produced for 10 patients with localised
prostate cancer mon planning objectives: (1) Treat R98% of the planning target volume (PTV) to R95% of the
prescription dose (74 Gy in 37 fractions); (2) keep OAR doses within predefined limits; (3) tr