碘-125放射粒子组织间植入治疗恶性肿瘤 PPT课件.ppt

文档介绍：Primary Clinical Study of CT-guided Iodine-125 Seed Implantation Therapy in Patients with Advanced Pancreatic Cancer
上海交通大学医学院附属瑞金医院卢湾分院

王忠敏
Brachytherapy
1898年居里夫人发现镭
1905年即进行了第1例镭针插管治疗
1930年Paterson及Parker建立了曼切斯特(Manchester)系统
1935年小居里夫妇发现了人工放射性同位素
80年代中期,现代近距离治疗迅速发展
生物学优势(外放疗相比)
肿瘤局部治疗的持续时间长
放射治疗的剂量较低
对周围正常组织的损伤小
对肿瘤细胞的杀伤力强
Implant radioactive seeds into tumors
Emit continueous low energy γ rays
Injury of tissues and cells
Cell death and mutation
leading to cancer
Interact with biomacromolecule
Animal experiment
Clinical research
Human pancreatic cancer Sw1990 cell
BABL/c was inoculated into the dorsal side of right lower
extremity inguinal region of nude mice
Passaged for 3 tims subcutaneously, initiate the experiments
after tumor formation was stablized
Experimental design
Subcutaneous pancreatic cancer xenograft in nude mice
Seed implantation group
Control group
Experimental method
Change of xenograft volume in nude mice
Comparison of tumor inhibition rate