文档介绍：止嗽立效胶囊的毒理学研究
作者:王卉,尤春来,穆培,李云兴
【关键词】止嗽立效胶囊;,,药理学;,,毒性
摘要:目的观察动物ig止嗽立效胶囊的急性毒性和长期毒性。方法 ig小鼠作急性毒性实验,观察中毒症状并测定LD50及95%平均可信限。 , , g・-1・d-1(临床人用量60,120,240倍)ig大鼠连续6周,观察大鼠的生长发育、血液学、血液生化学、脏器指数、组织病理学变化及停药2周后上述指数的变化。结果小鼠ig g・kg-1(胶囊), g・kg-1(生药)。长期ig中、高剂量可抑制雄性大鼠体重增长,低、高剂量组雌性大鼠脾脏重量减轻,低剂量组雌性、高剂量组雄性大鼠胸腺重量减轻。对各剂量组大鼠血液学有一定影响。其它指标均无明显异常。结论止嗽立效胶囊具有一定毒性。
关键词:止嗽立效胶囊; 药理学; 毒性
Toxicologic Study on Zhisoulixiao Capsule
Abstract:ObjectiveTo observe the acute toxicity of Zhisoulixiao Capsule(ZC)in mice and its long-period toxicity to The acute toxicity experiment ptoms of ZC in mice oderate and loinistered atological and hematobiochemical parameters, coefficient and histomorphological figure ans(the heart, liver, spleen, lungs, kidneys, adrenals, thymus, brain) ined in 6 ice. The body ale rats increased slooderate-dosage groups. The coefficient of spleen decreased in loale group and high-dosage female group. The coefficient of thymus decreased in loale group and high-dosage male group. ZC had a certain effect on has certain toxicity.
Key acology; Zhisoulixiao Capsule; Toxicity
止嗽立效胶囊是在止嗽立效丸基础上改变剂型的新药。它由麻黄、石膏、葶苈子、苦杏仁、甘草、***壳等中药组方。药效学研究表明其具有镇咳、祛痰、平喘作用。为保证临床用药的安全性,对止嗽立效胶囊进行毒理学研究。
1 材料
药物止嗽立效胶囊由辽宁中医药大学药学院中药系药剂教研室提供。批号990514。 g,实验用装胶囊前的颗粒用蒸馏水配成所用浓度的混悬液。
动物昆明种小鼠,18~22 g,雌雄各半