文档介绍：a(2000) 4, 113± 117
ORIGINAL ARTICLE
Local excisionwithout radiation for high-grade soft-tissue a of
theextremity and super® cialtrunk
LORNAM. WEIR, 1 ANTHONYB. V ANBERGEYK, 3 BASSAMA. MASRI, 3 CLIVE A.
GRAFTON,1 CLIVEP .DUNCAN, 3 KARENJ. GODDARD 1 & HOWARDA. JOE 2
1Departmentof Radiation Oncology, Br itish ColumbiaCancer Agency,V ancouver, 2Departmentof Radiation Oncology,
British ColumbiaCancer Agency,Victor ia and 3Departmentof Orthopaedics, Faculty of Medicine, University ofB ritish
Columbia,Vancouver,Canada
Abstract
Purpose. Limb-sparing bined with radiation treatment has ethe accepted treatment for patientswith
high-gradesoft-tissue a. Adjuvant radiationwas notroutinely used at this institutionfor patientswith clear margins
after retrospectivereview analyses e of this groupof patients.
Patients andmethods . Patientsstudied were referred from 1984to 1995, were over 16years of age,were diagnosed with
primary high-gradesoft-tissue a of theextremity or super® cialtrunk, had clearmargins after excisionand did not
receiveradiation as a part of theirinitial treatment. A totalof 46patients were identi® ed.
Results. At 5years, thelocal control rate was 87%,disease-speci® csurvival was 75%and overall survival was 68%.Of the
6local recurrences, 3 were located in the buttock (from a totalof 7patients with primary tumoursof thebuttock), 3 had a
primary sizeof ³ 10cm (from a totalof 8primary tumoursof thatsize) and all weredeep tumours.
Discussion. Ourdata, andthose from otherreports, suggestthat in carefully selectedpatients appropriate surgeryalone
resultsin acceptable local control and survival, andthat the morbidity of radiationcan be avoided.
Key words: softtissue a, local excision
Introduction Becauseof the morbidityassociated with
Soft as (STSs) are rare neoplasms, adjuvant radiation,it has notbeen used routinely at
accountingfor approximately 1% of cancercases ourinstitution in the managementof primary ST