文档介绍：• 1882 •中华中医药杂志(原中国医药学报)2012年7月第27卷第7期 CJTCMP , July 2012, Vol . 27, No. 7
·综述·
自乳化释药系统在难溶性中药制剂中的应用
叶珍珍,张建,崔升淼
(广东药学院中药学院中药制药系,广州 510006)
摘要:自乳化释药系统可以提高难溶性药物的溶出度和生物利用度,在中药方面的应用具有良好的发展前
景。文章综述自乳化释药系统的定义、特点、体内外质量评价指标、在难溶性中药制剂中的应用以及存在问题与
对策。
关键词:自乳化药物释放系统;生物利用度;质量评价;难溶性中药
基金资助:广东省科技计划项目([2011]106,),广东省中医药局建设中医药
强省科研项目(),广东药学院重点培养教师资助计划
Self-emulsifying delivery systems and its application on preparations of poorly soluble
Chinese materia medica
YE Zhen-zhen, ZHANG Jian, CUI Sheng-miao
( Department of TCM Pharmaceutics, School of Traditional Chinese Materia Medica, Guangdong Pharmaceutical University,
Guangzhou 510006, China )
Abstract: The dissolution and the bioavailability of water-insoluble drugs can be improved by the utilization of self-
emulsifying delivery systems (SEDDS), so SEDDS has a promising application in the field of Chinese medicine. The definition,
characterization, indexes in vivo and in vitro evaluations, application to preparations of poorly soluble Chinese materia medica,
problems and countermeasures are reviewed.
Key words: Self-emulsifying delivery systems; Bioavailability; Quality evaluation; Poorly soluble Chinese materia
medica
Fund assistance: Science and Technology Project of Guangdong Province(No.[2011]106, ),
Construction of Strong Medicine Scientific