文档介绍：静脉滴注胺碘酮致肝肾功能不全1例及其文献复习
罗敏1*,李思远2,唐尧1#
四川大学华西医院药剂科,成都610041
四川大学华西医院老年科,成都610041
摘要通过报道1例静脉滴注胺碘酮致肝肾功能不全的案例,回顾学习胺碘酮致肝肾功能不全的相关文献,进行静脉胺碘酮致肝肾功能不全的可能性评估,探讨胺碘酮静脉滴注致肝功能不全的的作用机制,进而提出胺碘酮静脉使用的药学监护,以引起临床医师和临床药师高度重视,从而及时识别和防治胺碘酮所致肝肾功能不全。
关键词胺碘酮;肝功能不全;肾功能不全;文献复习
Intravenous amiodarone induced hepatic and renal insufficiency: A case report and review of the literature
LUO Min1,LI Si Yuan2,TANG Yao1
. of Pharmacy, West China Hospital of Sichuan University, Chengdu 610041, China
. of Geriatrics,West China Hospital of Sichuan University, Chengdu 610041, China
Abstract We reported one case of intravenous amiodarone induced hepatic and renal insufficiency ,assessed the possibility of the adverse drug reaction,reviewed related literature of the mechanism of amiodarone induced hepatic insufficiency, and summarize the pharmaceutical care points,These were hoped to attract the attention of clinicians or clinical pharmacists, in order to Timely recognize and effectively prevent or treat Intravenous amiodarone induced hepatic and renal insufficiency.
Key words Amiodarone;Hepatic insufficiency;Renal insufficiency;Literature review
胺碘酮是含碘苯唑呋喃衍生物,最早应用于临床是作为抗心绞痛药物,在其应用的过程中发现抗心律失常作用,现被认为是最有效的广谱抗心律失常药物[1]。国内外相继出台了一系列的胺碘酮临床合理使用的相关指南[2,3]。但鉴于胺碘酮自身固有的药理药动学特性及其心脏及心脏外的毒副作用使其在临床上的选用仍存在一定的限制。胺碘酮严重的心脏毒副作用为引发严重的心律失常作用,其严重的常见的心脏外毒副作用有甲状腺功能不全、角膜微沉淀、肺纤维环等。静脉使用胺碘酮常见的不良反应有静脉炎、低血压、心动过缓等,而导致严重的肝肾功能