文档介绍：天然产物研究与开发 Nat Prod Res Dev 2006, 18: 105-107
文章编号: 1001- 6880( 2006) 01-0105- 03

赤芍中芍药苷提
取工艺的优化
1, 2 1* 1
潘浪胜, 吕秀阳, 吴平东
( 1. 浙江大学材料与化工学院制药工程研究所, 杭州 310027; 2. 湘潭大学化工学院, 湘潭 411105)
摘
要: 本文提出一条从赤芍中提取芍药苷的工艺, 包括醇水溶液回流提取、液液分配、硅胶柱层析等工序, 并
对各工序的操作条件进行了优化。采用优化后的提取工艺, 可得到纯度大于 97
0% 的芍药苷产品, 总回收率超
过 87
0% 。本工艺具有产品纯度高、操作简单、成本低、回收率高、易于工业化等优点。
关键词: 赤芍; 芍药苷; 提取; 工艺优化
中图分类号: R284
2; Q946. 91 文献标识码: A
Process Optimization of Paeoniflorin Isolation from Paeonia veitchii Lynch
PAN Lang-sheng1, 2, LV Xiu-yang1* , WU Ping-dong1
(1. Institute of Pharmaceutical Engineering , College of Materials Science and Chemical Engineering, Zhejiang University ,
Hangzhou 310027, China; 2. College of Chemical Engineering , Xiangtan University , Xiangtan 411105, China)
Abstract:Paeoniflorin is the major pound in Paeonia veitchii Lynch. A process was established for isolating paeon-i
florin from Paeonia veitchii Lynch, which includes extraction of Paeonia veitchii Lynch with ethano-l water solution, liquid- liquid
extraction and silica gel column operating parameters in each step were optimized. With the process opt-i
mized, paeoniflorin with a purity over 97. 0% can be prepared with the total recovery more than 87. 0% . High purity products
can be obtained with this process which is simple, low cost, high recovery and easy to scale up.
Key words: Paeoni