文档介绍：·3160 · 现代生物医学进展 gress in Modern Biomedicine
溃疡性结肠炎发病机制研究进展
赵曼 1 高峰 2△
(1 新疆医科大学新疆乌鲁木齐 830054;2 新疆维吾尔自治区人民医院消化科新疆乌鲁木齐 830001)
摘要:溃疡性结肠炎是一种常见的慢性肠道疾病,近年来发病呈上升趋势,而其发病机制目前尚不明确,目前认为与多种因素有
关。其中免疫异常被认为是该病发病的重要因素,主要包括自身抗体、细胞免疫、细胞因子、环氧合酶与基质金属蛋白酶、氧自由
基和一氧化氮等。但是遗传因素,感染因素,精神因素,饮食因素等均在其发生和发展中亦起着一定作用。本文就溃疡性结肠炎发
病机制的各种影响因素予以综述。
关键词:溃疡性结肠炎;发病机制;免疫因素;遗传因素
中图分类号: 文献标识码:A 文章编号:1673-6273(2010)16-3160-06
New Progress in the Pathogenesis of Ulcerative Colitis
ZHAO Man1, GAO Feng2△
(1 XinJiang Medical University,Urumqi 830054,China;
2 Department of Gastroenterology of the People's Hospital of XinJiang Uygur Autonomous Region,Urumqi 830001,China)
ABSTRACT: Ulcerative Colitis is a chronic inflammatory disease of the gastrointestinal tract. The morbidity of the disease has in-
creased in recent years while the precise etiology of it remains unknown. Now many factors are thought to be associated with it. Immune
system is very important. Following factors, such as antibodies, immune cells, cytokines, COX and MMP, O2- and NO, play a key role in
the pathogenesis of this disease. But it is all related to Ulcerative Colitis that ic factors, infectious factor, psychic factor and diet fac-
tor. This article reviewed these influence factors about the etiology of ulcerative colitis.
Key words: Ulcerative colitis; Pathogenesis; Immune factors; ic factors
C