文档介绍：中国组织工程研究与临床康复第 15 卷第 33 期 2011–08–13 出版
Journal of Clinical Rehabilitative Tissue Engineering Research August 13, 2011 ,
基因敲除模型小鼠在疾病研究中的应用
石玉衡
Gene knockout mouse models for disease study

Shi Yu-heng

Abstract
BACKGROUND: Many diseases in human are determined by genes. Constructing corresponding gene knockout animal models is College of Food
Science &
of significance for treatment of diseases and studying the underlying pathological mechanisms. Technology, Nanjing
OBJECTIVE: To investigate the application and research progress of knockout mouse models in studying cardiovascular, Agricultural
neurological, bone, liver, retinal diseases. University, Nanjing
210095, Jiangsu
METHODS:
puter-based retrieval was performed to search manuscripts regarding knockout mouse models KI and Province, China
PubMed published between January 1990 and December 2009 with the key words “knockout mouse, atherosclerosis, nervous
system, osteoporosis, liver, retina” in Chinese and English language. Manuscripts evaluating knockout mouse models with original Shi Yu-heng, College
of Food Science &
and reliable evidence were included and those with repetitive contents or Meta analysis papers were excluded. Technology, Nanjing
RESULTS AND CONCLUSION: Total 75 manuscripts were retrieved, and according to inclusion and exclusion criteria, 38 Agricultural