文档介绍：Development of Survivin and Tumor Research
JI Yu-bin1,2,3, LIU Guang-da *1,YU Lei1,2,3, LI Hai-jiao 1,YANG Hai-fan1,PANG Lin-lin1
(1 Center of Research and Development on Life Sciences and Environmental Sciences, Harbin University merce, Harbin 150076, China; of Materia Medica and Postdoctoral Programme of Harbin University merce, Harbin 150076, China; Reseach Center of Natural Anticancer Drugs,Ministry of Education)
Abstract:Objective Survivin was firstly separated in hybridization of Effector Cell Protease Receptor-1(EPR-1) cDNA in human genome by Yale University's Ambrosini in 1997,which is member of the inhibitor of apoptosis proteins(IAPS).Unlike other IAP protein,found during embryonic and fetal development,survivin pletely down-regulated and undetectable in normal adult tissues,and became prominentlyre expressed in all of the mon through includes the cysteine/histidine rod-shaped viral IAP repetition sequence baculoviral IAP repeats(BIRs) the structure territory directly or intervenes Caspases the function to display indirectly its anti-perishes weakly the function, simultaneously it also is in the cell division process the chromosome traveler protein (chromosome passenger protein).There are three approaches by which survivin inhibits the processing of apoptosis:(1)inhibits processing of down stream effector caspase-3,caspase-7and c