文档介绍：溃疡性结肠炎的诊治进展
Introduction
IBD是一种病因尚不十分清楚的慢性非特异性肠道炎症,包括UC和CD 。
其发病率呈逐年上升趋势,且多为青壮年发病,临床表现复杂,并发症严重,肠外表现多样,严重影响个人生活质量和社会生产力。
此外,因其有癌变的风险,备受广大医生的重视。
近年来在国内外IBD基础与临床研究高潮迭起,基础研究的成果直接指向临床治疗,取得了划时代的进展。
探讨和摸索适合国人的治疗方案以降低重症UC的并发症和死亡率显得十分重要。
Introduction
Ulcerative colitis is characterized by mucosal inflammation of the colon.
The pathology is inflammatory and the disease course is relapsing and remitting with intermittent symptoms of rectal bleeding and diarrhea.
Approximately 25% of patients develop a chronic active or a rapidly fulminate disease course.
Chronic inflammation can lead to dysplasia and cancer.
Approximately 20% of patients require colectomy with ileoanal pouch or stoma.
Velayos FS, Terdiman JP, Walsh JM. Effect of 5-aminosalicylate use on colorectal cancer and dysplasia risk: a systematic review and metaanalysis of observational studies. Am J Gastroenterol 2005;100:1345–1353.
Consensus
Stange EF, Travis SP, Vermeire S, Reinisch W, Geboes K, Barakauskiene A, et al. European evidence-based Consensus on the diagnosis and management of ulcerative colitis: definitions and diagnosis. J Crohns Colitis 2008;2:1–23.
Van Assche G,Dignass A,Panes J,et second European evidence-based Consensus on the diagnosis and management of ulcerative colitis:Definitions and Crohns Colitis,2010·4:7 27.
Mowat C, Cole A, Windsor A, Ahmad T, Arnott I, Driscoll R, et al. Guidelines for the management of inflammatory bowel disease in adults. Gut 2011;60:571–607.
Turner D, Levine A, Escher JC, Griffiths AM, Russell RK, Dignass A, et al. Management of pediatric ulcerative colitis: a joint ECCO and ESPGHAN evidence-based consensus guidelines. J Pediatr Gastroenterol Nutr 2012.
Turner D, Travis SP, Griffiths AM, Ruemmele FM, Levine A, Benchimol EI, et al. Consensus for managing acute severe ulcerative colitis in children: a systematic review and joint statement from ECCO, ESPGHAN, and the Porto IBD Working Group of ESPGHAN. Am J Gastroenterol 2011;106:574–88.
Managemen