第35章 肾上腺皮质激素类药物.ppt

文档介绍：School of Pharmaceutical Sciences
Southern Medical University
Adrenocortical Hormones
CORTEX
(皮质)
ZONAGLOMERULOSA
(球状带)
MINERALOCORTICOIDS (ALDOSTERONE,醛固酮)
ZONAFASICULATA
(束状带)
GLUCOCORTICOIDS (CORTISOL,可的松)
PREDOMINANTLY
ZONARETICULARIS
(网状带)
Sex hormones
MEDULLA(髓质)
CATECHOLAMINES (EPINEPHRINE AND NOREPINEPHRINE)
LIVER
FATS
MUSCLE
BLOOD CELLS
Hypothalamus
(corticotropin releasing factor)
+
CORTISOL
Pituitary
(corticotropin)
+
FEEDBACK
CONTROL
OF CORTISOL
SECRETION
-
-
LIVER
FATS
MUSCLE
BLOOD CELLS
Adrenal gland
Structure-activity relationship
Basal structure of adrenocortical hormones
Section 1
Glucocorticoids
Physiological Functions
Pharmacological effects
ics
Mechanism of actions
Clinical uses
Adverse effects and contraindications
Dosage schedule
PHYSIOLOGIC EFFECTS OF GLUCOCORTICOIDS
CARBOHYDRATES
PROTEINS
FATS
Carbohydrate metabolism
Protein metabolism
Fat metabolism