精神疾病的神经生物学基础及精神病药物作用机理.ppt

文档介绍：精神疾病的神经生物学基础及精神病药物作用机理
abnormal gene
INHERITED DISEASE
100% will develop the inherited disease (classical autosomal dominant pattern)
4-1
Stahl S M, Essential Psychopharmacology (2000)
abnormal gene product
RISK FACTOR 1
an enzyme is too slow ever since birth so it is hard to metabolize neurotransmitters when release is very fast
RISK FACTOR 2
some neurons migrated too far during development in utero
RISK FACTOR 3
some of the wrong synapses were eliminated in adolescence
RISK FACTOR 4
nerves fire too fast when you see your mother
1-3 are inherited ic “hits”- 4 & 5 are environmental “hits” expressed through abnormal ic responses
RISK FACTOR 5
nerves fire too fast when you take “speed”
4-2
Stahl S M, Essential Psychopharmacology (2000)
LIFE EVENTS
FILTER
personality/coping skills
ic vulnerability factors for depression
4-3
Stahl S M, Essential Psychopharmacology (2000)
even if you inherit the gene for Schizophrenia, the chances of whether or not you develop the disease may be affected by outside factors
bad childhood
divorce
virus or toxin
schizophrenia
4-4
Stahl S M, Essential Psychopharmacology (2000)
MINOR STRESSORS
(DNA with predisposition for schizophrenia -- highly biologically determined)
SCHIZOPHRENIA
MODERATE STRESSORS
(DNA with predisposition for depression -- moderately biologically determined)
DEPRESSION
MAJOR STRESSORS
(“normal” DNA)
PTSD
4-5
Stahl S M, Essential Psychopharmacology (2000)
good neuronal selection
= healthy
neuron
= defective
neuron
bad neuronal selection
4-6
Stahl S M, Essential Psychopharmacology (2000)
bad migration
good migration
4-7
Stahl S M, Essential Psychopharmacology (2000)
CORRECT WIRING
4-8
Stahl S M, Essential Psychopharmacology (2000)
WRONG WIRING
4-9
Stahl S M, Essential Psychopharmacology (2000)