文档介绍：2型糖尿病患者颈动脉内膜-中层厚度与血浆LPA含量的关系
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作者:吕肖锋,刘凯燕,刘福平
【摘要】目的探讨2型糖尿病患者(T2DM)颈动脉内膜-中层厚度(IMT)、斑块形成情况与血浆溶血磷脂酸(LPA)含量的关系。方法采用彩色多普勒超声测定64例T2DM患者与40例正常对照组IMT及斑块。并采用无机磷定量法提取全部受试者血浆LPA。结果 T2DM患者较正常对照组IMT明显增厚,正常对照组无颈动脉狭窄,%有颈动脉狭窄。线性回归分析显示:两组IMT与血浆LPA含量呈正相关。结论 T2DM患者IMT、斑块形成与血浆LPA含量呈高度正相关。
【关键词】 2型糖尿病;颈动脉内膜-中层厚度;血磷脂酸
Abstract: Objective To study the relationship between carotid intimamedia thickness, plaque formation and plasma LPA content in patients with type 2 Color Doppler ultrasound was used to exam IMT and plaque of 64 cases of T2DM group and 40 cases of normal control group. And all subjects
’ plasma LPA were extracted by means of quantitative anic phosphorus. Results T2DM group is obviously thicker than normal control group IMT, the normal control group have no carotid stenosis, % cases of T2DM group have carotid artery stenosis. Linear regression analysis showed that: IMT and plasma LPA content of the two groups was positively correlated. Conclusion T2DM groups IMT、plaque formation and plasma LPA content was highpositive correlation.
Key words: type 2 diabetes;carotid inrimamedia thickness;lysophosphatidic acid
早期发现、防治动脉粥样硬化(AS)对2型糖尿病(T2DM)患者非常重要。本研究采用彩色多普勒超声测定北京军区总医院2008年1—10月64例2 型糖尿病患者及40例健康体检者颈动脉内膜-中层厚度(IMT)、斑块形成情况,同时采用无机磷定量的方法检测受试对象血浆溶血磷脂酸(LPA)浓度,并探讨二者间的相关性及在AS进展中的作用,为T2DM患者在早期干预和防治心脑血管病变提供依据。