文档介绍：Elf1在胃癌组织中的表达及其临床意义
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【摘要】目的探讨转录因子Elf1在胃癌组织中的表达及其与胃癌临床病理学特征的关系。方法采用免疫组织化学染色的方法检测70例胃癌组织及相应的癌旁组织、远癌黏膜组织中Elf1的表达,分析Elf1表达与胃癌及其临床病理特征的关系。结果 Elf1在胃癌、癌旁组织、%、%、%,Elf1在胃癌中的表达率明显高于癌旁组织及远癌黏膜组织,差异有显著性(Hc=,);Elf1在胃癌中的表达与分化程度、浸润深度、临床分期及淋巴结转移有关(Hc=-~,)。结论Elf1与胃癌的发生及发展有关,检测Elf1的表达水平对于胃癌早期诊断及预后评估具有重要参考价值。
【关键词】 Elf1 癌基因胃肿瘤免疫组织化学
[ABSTRACT] Objective To investigate the expression of Elf1 in human gastric carcinoma and its relation to clinical pathology. Methods Elf1 expressions in cancer tissue and adjacent and distal mucosa, in 70 cases, were investigated by immunohistochemistry. The relationship between the expressions and the path
ological characters was analyzed. Results The positive expressions of Elf1 in the cancer,adjacent tissues and distal mucosa were %,%, and %, respectively, the difference between them being significant (Hc=,). Elf1 expression was correlated with differentiation, staging, depth of invasion and lymph node metastasis (Hc=--,). Conclusion Elf1 is involved in tumorigenesis and progression of gastric cancer. The detection of Elf1 is of great reference in an early diagnosis and prediction of prognosis of gastric carcinoma.

[KEY WORDS] Elf1; Oncogenes; Stomach neoplasm; Immunohistochemistry

Elf1是ETS转录家族中的一员