文档介绍：HBeAg阴性与HBeAg阳性乙肝肝硬化患者临床相关因素对比分析
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作者:丁向春,马丽娜,张栩,李玉芳,张平
【摘要】目的探讨HBeAg阴性与HBeAg阳性肝炎肝硬化的临床相关因素异同。方法对424例乙肝肝硬化中HBeAg阴性与HBeAg阳性肝炎肝硬化患者HBV-DNA 水平、并发症和Child-pugh分级资料进行回顾性分析。结果 424例乙肝肝硬化中HBeAg阴性患者 252例,%;HBeAg阳性患者 172例,%;HBeAg阴性组年龄明显高于HBeAg 阳性组(P<);HBeAg阴性组 HBV-DNA 水平低于HBeAg阳性组(P<);HBeAg阴性组原发性肝癌发生率高于HBeAg阳性组(P<);两组间性别、各并发症发生率和Child-pugh分级水平、差异无统计学意义(P>)。结论乙肝肝硬化中HBeAg阴性患者年龄较大、HBV-DNA 水平较低、原发性肝癌发生率较高;HBeAg阴性组和阳性组在其它并发症发生率和病情轻重方面未见区别。
【关键词】肝炎肝硬化;HbeAg;HBV-DNA; Child-pugh分级;原发性肝癌
Abstract: Objective To investigate pare the clinical characteristics of HBeAg-negative and HBeAg-positive liver A total of 424 hospitalized cases with HBeAg-negative and HBeAg-positive liver cirrhosis were analyzed factors included age,gender,constitutes of liver cirrhosis,HBVDNA plications and Child-pugh HBeAg-negative liver cirrhosis patients group totally 252 cases,215 male and 37 female,the gender ratio was roughly :-positive chronic liver Diseases patients group totally 172 cases,149 male and 23 female,the gender ratio was roughly ∶ serum HBVDNA levels in HBeAg-negative patients group was lower than that in HBeAg-positive patients group (P<).No significant difference was found in upper gastrointestinal hemorrhage,hepatic encephalopathy,infection of ab