文档介绍：
Implication of urinary KIM-1 mRNA detection in
nephropathy patients with type 2 diabetes#
LV Linli1, ZHENG Min2, NI Jie2, MA Kunling3*
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(1. Southeast University, School of Medicine/Institute of Nephrology, NanJing 210009;
2. Southeast University, School of medicine, NanJing 210009;
3. Southeast University, Zhongda hospital, NanJing 210009)
Abstract: In this paper, the purpose of this study was to investigate the role of Kidney Injury
Molecule-1(KIM-1) mRNA expression in urinary sediment for evaluating the progression of diabetic
nephropathy(DN) patients with type 2 total of 46 patients with diabetes and 14 healthy
controls were studied. Urinary KIM-1 mRNA expression was measured, and correlations with renal
functional parameters were investigated. Urinary KIM-1 mRNA was significantly increased in patients
compared with healthy controls (p=). The mRNA level increased with increasing levels of
albuminuria and correlated with serum creatinine (r=, P <), BUN (r=, p<), and
eGFR(r=-, p=). And it could separate DN from controls with AUC of . KIM-1 mRNA
could reflect the progression of DN and might be a novel, early and non-invasive biomarker for DN.
Keywords: urinary messenger RNA; diabetic nephropathy; biomarker; Kidney Injury Molecule-1
0 Introduction
Diabetic nephropathy (DN) is a