文档介绍：
TGFβ信号通路在肝病发生和治疗中应用
前景的研究进展#
张森,孙妩弋,吴晶晶,魏伟**
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(安徽医科大学临床药理研究所,抗炎免疫药物教育部重点实验室,合肥 230032)
摘要:转化生长因子β(transforming growth factor β, TGFβ)是一类多功能的细胞因子,参
与调控胚胎发育、创伤愈合、细胞增殖和分化等过程。此外,在多种肝病的发病机制中,
TGFβ也发挥着调控作用。肝脏内多种细胞都能合成分泌 TGFβ,并表达 TGFβ的相关受体,
通过不同的信号通路在肝病进程中起到至关重要的作用。本文将对 TGFβ信号通路在肝病发
生发展中的作用及以其为靶点的肝病治疗药物的研究进展作一综述。
关键词:药理学;转化生长因子β;信号通路;肝纤维化;肝癌;靶向治疗药物
中图分类号:R96
Targeting the TGFβ signaling pathway in the treatment of
liver diseases
ZHANG Sen, SUN Wuyi, WU Jingjing, WEI Wei
(Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of
Antiinflammatory and Immune Medicine, Ministry of Education, HeFei 230032)
Abstract: Transforming growth factor β(TGFβ) exerts multifunctional roles in the process of
embryonic development, wound healing, cell proliferation and differentiation. Moreover, TGFβ is
also involved in the pathogenesis and development of various liver diseases. A variety of liver
cells are considered to secrete TGFβ ligands and express related receptors, and consequently play
a crucial role in the progression of liver disease via different signal pathways. In this paper, the
role of TGFβ signaling pathway in liver disease and targeting the TGFβ signaling in the treatment
of liver disease are reviewed.
Keywords: transforming growth factor β; signal pathway; liver fibrosis; liver cancer; targeted
therapeutic dru