文档介绍：上海交通大学
硕士学位论文
急性脑梗死的溶栓治疗
姓名：张彬
申请学位级别：硕士
专业：神经内科
指导教师：孙晓江
20080401
上海交通大学 2005 级硕士学位论文 
等级为 III 级的，预后良好的％；再通等级为 II 级的，预后良好
的 25％。
3. 动静脉溶栓的比较：静脉组和动脉组疗效和安全性的比较无差
异（P>）。大脑中动脉闭塞，静脉溶栓预后良好的占％，动脉
溶栓预后良好的占％。
结论：
、治疗时间窗无关。房颤病人的出血率和死
亡率较高。
。
，大脑中动脉闭塞，
动脉溶栓效果较好。

关键词：急性脑梗死，rt-PA,溶栓
上海交通大学 2005 级硕士学位论文 
THROMBOLYSIS FOR
THE ACUTE ISCHEMIC STROKE

  ABSTRACT
 
Objective:
To investigate the efficacy and safety of thrombolysis, and to compare the
outcome and the safety between the intravenous and intra-arterial
thrombolysis, and analysis the factors related to the outcome.
Methods:
110 cases of acute ischemic stroke patients were treated with rt-PA.
Comparing the scores of the NIHSS and ESS before and after thrombolysis,
to evaluate the safety and efficiency of thrombolysis，using mRS to evaluate
the prognosis after three month of thrombolysis.
Results:
1. Intravenous thrombolysis: the patients with good outcome were
%, the incidence of the SICH was %, and the death rate was %.
The patients’ age and the time window had no relation with the safety of
thrombolysis. The effeciency of affiliated patients was similar to the
non-affiliated patients, but affiliated patients had higher bleeding rate and
death rate. The baseline NIHSS cores was related to the symptomatic
intracranial haemorrhage（OR=，P＝<，95% CI to
）, and the 14 days NIHSS scores was related to the outcome
（OR=, P＝<，95% CI －）.
2. Intra-arterial thrombolysis: the patients with good outcome were
上海交通大学 2005 级硕士学位论文 
%, the incidence of the SICH