文档介绍：1 胸腺癌 1 例临床病理分析作者:陈鑫,晏培松,步雪,何粉玲,贾旭春,杜波, 刘建【摘要】目的探讨胸腺癌的组织形态特征及其分型。方法运用光镜、电镜和免疫组化, 观察本例胸腺癌的镜下特点和免疫组化表型。结果肿瘤组织附带部分包膜,瘤细胞弥漫排列, 或排列呈胸腺小体样、血管瘤样、真或假菊形团样、癌肉瘤样改变。细胞界限部分清楚, 部分不清, 胞浆少淡嗜伊红色, 部分胞浆透亮, 瘤细胞核圆形、卵圆形、不规则形、梭形, 染色质细, 可见病理性核分裂相。 Vim , S-100 , Ki67 阳性, Keratin , EMA , CEA , NSE , CD20 , CgA , Sy n 均为阴性。结论胸腺癌是纵隔少见的恶性肿瘤,肿瘤细胞形态学具有多样性。【关键词】胸腺肿瘤;病理形态;免疫组化 Primary thymus carcinoma :a case report and review of the literature 2 [ Abstract ] Objective To investigate the clinic pathological characteristics of thymus We studied one case of Thymus carcinoma ( TCA ) by light microscopy , immunohistochemistry and electron microscopy and correlated the findings with clinical TCA isa thymus epithelial neoplasm with obvious cytological atypism. The arrangement of tumor is multiplicity , such as mainly diffuse , thymus corpuscle change , angiomatous change , and a expression of Vim , Ki67 were detected by immunohistochemical Primary thymus carcinoma is rare in the mediastinum and histological patterns are various. [ Key words ] tumour of thymous ; pathological figure ; immunohistochemistry 胸腺癌起源于胸腺上皮细胞,是非常少见的纵隔肿瘤,仅占原发于前纵隔肿瘤的 6% [1]。 2004 年最新版 WHO 分类将胸腺癌分为鳞状细胞癌、基底样癌、黏液表皮样癌、淋巴上皮瘤样癌、肉瘤样癌、透明细胞癌、腺癌、未分化癌等; 另外, 胸腺的神经内分泌癌也属于原发于胸腺的一大类恶性 3 上皮性肿瘤, 其中典型类癌和不典型类癌均属于分化好的类型,小细胞癌和大细胞性神经内分泌癌则归为分化差的类型。我们参照 WHO 新分类,结合免疫组化及本例的病理形态学特点,可视为多形性型。 1 材料与方法 标本