PFC脑区促进睡眠神经元课件.ppt

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LvFei

CorrespondingAuthor
YangDan,PhD
BS,physics,BeijingUniversity
PhD,neurobiology,ColumbiaUniversity
Currentpositions
HowardHughesMedicalInstitute
UniversityofCalifornia,Berkeley
Currentprojects
Neuralcircuitscontrollingsleep.
Functionoftheprefrontalcortex(PFC).
Background
Differentwaves
-sleep-
Background
Sleepcycle
-sleep-
Background
TMN
Tuberomammillarynucleus,aregionoftheposteriorhypothalamus
largely,wake-promotinghistaminergicneurons
arousal,learning,memory,sleepandenergybalance.

GABAPOA→TMN
ExtendedDataFigure1a
GABAPOA→TMNsinglesoutthesleep-promotingneurons
GABAPOA→TMN
±%
±%
ExtendedDataFigure2h
GABAPOA→TMNsinglesoutthesleep-promotingneurons
GABAPOA→TMN
±%
Sleeprebound
GABAergicneurons
histaminergicneurons
POA
TMN
GABAPOA→TMN
Sleep-promoting
ExtendedDataFigure2i
Twopartsoftheessay
Identificationofpreopticsleepneuronsusing
retrogradelabellingandgeneprofiling
Retrogradelabelling
Causalrole:Optogeneticactivationorinhibitionof
GABAPOA→TMNneuronsenhancesorsuppressessleep.
Figure1
Extendeddatafigure3