喹诺酮类药对常见病原菌耐药变迁与耐药机制初探.pdf

文档介绍：调查研究年月第卷第期
· · 2011 2 8 5
喹诺酮类药对常见病原菌耐药变迁与耐药机制初探
黄小玲 1,林渡娣 1,杨春燕 1,黄福新 2,袁慧文 3
深圳市慢性病防治中心广东深圳深圳市福田人民医院广东深圳
(1. , 518020;2. , 518033;
深圳市药品检验所广东深圳
3. , 518029)
了解喹诺酮类药对临床常见病原菌的耐药性变迁及耐药机制采用法国分析仪进
[摘要] 目的: 。方法: Vitek-32 AMS
行鉴定纸片扩散法进行药敏试验根据美国临床实验室标准化研究所标准判断结果并查阅文献初探细菌
, ; (CLSI) ,
耐药机制依据喹诺酮类药对常见和菌株耐药性的监测结果耐药性均有不同程度增加其耐药
。结果: G+ G- 4 060 , ,
性排序为环丙沙星左氧氟沙星加替沙星莫西沙星环丙沙星对和的耐药率分别超过和
> > > , MRSA S %
已高度耐药临床不应再作为首选用药细菌耐药机制主要是细菌内药物累积浓度降低靶酶或靶位点基
%, , 。, ,
因突变质粒介导引起耐药或多重耐药喹诺酮类药耐药性逐年增加从耐药机制看临床除应做药敏试验外
, 。结论: , , ,
还应根据参数优选药物及给药剂量
PK/PD 。
[关键词] 喹诺酮类药物;G+球菌;G-杆菌;耐药性变迁;耐药机制
[中图分类号] [文献标识码] C [文章编号] 1673-7210(2011)02(b)-128-03
Change of resistance and drug resistance mechanism of quinolone against
common bacteria in clinical practice
HUANG Xiaoling1, LIN Dudi1, YANG Chunyan1, HUANG Fuxin2, YUAN Huiwen3
( Chronic Disease Prevention and Cure Centre, Shenzhen 518020, China; 2. Futian People's Hospital of Shen -
zhen City, Shenzhen 518033, China; 3. Shenzhen Institute of Drug Control, Shenzhen 518029 )
[Abstract] Objective: To understand change of resistance and drug resistance mechanism of quinolone mon
bacteria in clinical practice. Methods: To identify by French Vitek-32 AMS analyzer, susceptibility test was performed
with disc diffusion testing. The results were evaluated according to the standards of US Clinic