文档介绍：Kawasaki Disease
Department of Pediatric
Wang Xiu-ying
中南大学儿科学教研室
第九章第八节
■Understand the etiology and pathology of Kawasaki Disease (K D)
■Master the clinical manifestations and diagnostic criterion of KD.
■Master the treatment of KD.
Purpose and Requirement
Kawasaki disease formerly known as mucocutaneous lymphnode syndrome(MCLS 皮肤粘膜淋巴结综合征). 80% of patients are younger than 5yr, Approximately 20% of untreated patients develop coronary artery abnormalities including aneurysms
(动脉瘤).kawasaki disease has replaced acute rheumatic fever as the leading cause of acquired heart disease in children in our country.
Conception
Etiology and Pathogenesis
※infectious factors(感染因素)
※ immune reaction(免疫反应)
※ other factors(其他因素)
A severe vasculitis(血管炎) of all blood vessels
Arteria(动脉)
Vena(静脉)
Capillary(毛细血管)
PATHOLOGY
Fever
Rash of various forms(多形红斑)
Mucosa vary(粘膜变化)
Cervical lymphnode swelling
(颈淋巴结肿大)
Changes of the peripheral extremities (周围四肢的变化)
CLINICAL MANIFESTATION
Rash involving the trunk and the extremites
Rash of various forms
Swelling of the hands
Swelling of the feet
Periungual desquamation tips of the fingers and toes