文档介绍：C反应蛋白基因启动子T757C多态性与不稳定性心绞痛的关系
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作者:戚猛, 何, 高磊, 沈丹丹, 金鸣锋, 张寄南
【摘要】目的: 探讨中国苏皖地区汉族人群C反应蛋白(Creaction protein, CRP)基因启动子T757C多态性与不稳定性心绞痛(unstable angina pectoris, UAP)的可能关系。方法: 采用病例对照研究方法,以165例UAP 患者(病例组)和282例非冠心病者(对照组)作为研究对象,应用聚合酶链反应-限制性片段长度多态性(polymerase chain reactionrestriction fragment length polymorphism,PCRRFLP)方法检测CRP基因T757C多态性。结果: 与对照组相比,UAP组的TT,基因型频率比较均无统计学意义()。 %%,两组间差异无统计学意义()。多元Logistic回归分析显示CRP基因T757C多态性与UAP的发生无显著性关联()。结论: 在中国苏皖地区汉族人群中,CRP基因启动子T757C多态性与UAP无显著相关性。
【关键词】 C反应蛋白; 基因多态性; 不稳定性心绞痛
[Abstract] Objective: To investigate the possible association between C
reaction protein(CRP) gene T757C polymorphism in the promoter region and unstable angina pectoris(UAP) in a Chinese Han population of Suwan region. Methods: This study was conducted with a casecontrol design including 165 patients with UAP(UAP group) and 282 control subjects who were free from coronary artery disease(control group). The T757C polymorphism in CRP gene was determined by polymerase chain reaction and restriction fragment length polymorphism analysis. Results: Compared with the control group, the frequencies of TT,TC genotype were not significantly different in UAP group(). The prevalence of T allele was % and %() respectively in the UAP group and control group. Multiva