文档介绍：2型糖尿病肾病与中心性肥胖的相关研究
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【摘要】目的研究2型糖尿病肾病(DN)与中心性肥胖之间的关系。方法应用Logistic回归分析方法回顾性分析352例2型糖尿病患者的年龄、病程、血压、体重指数、腰臀比、空腹血糖、糖化血红蛋白、血脂等与糖尿病肾病间的相关性。结果糖尿病肾病(DN)组的病程、体重指数、腰臀比、三酰甘油、胆固醇、低密度脂蛋白、尿素氮、肌酐均明显高于糖尿病非肾病(DM)组;Logistic回归分析提示DN与病程、腰臀比、三酰甘油、胆固醇、低密度脂蛋白有相关性。结论减轻体质量,控制血脂、血压、血糖可在某种程度上延缓DN的发生与发展。
【关键词】糖尿病肾病;尿白蛋白排泄率;中心性肥胖
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【Abstract】 Objective To study the relation between diabetic nephropathy in type 2 diabetic patients and central obesity. Methods The relation was retrspective analysed with logistic regression between 352 type 2 diabetic patients
’age,durationof diabetes,blood pressure,body mass index ,waist-to-hipratio,fasting plasma glucose ,glycosylated HbA1c,blood lipid and diabetic nephropathy. Results Durationg of diabetes,body mass index ,waist-to-hipratio,TG,TC,LDL-C,Urea nitrogen,Creatinine were higher in those in DN group than those in DM group. The logistic regression suggested the relation between diabetic nephropathy and durationg of diabetes,waist-to-hipratio,TG,TC,LDL- To control body weight,blood lipid,blood pressure,serum glucose can delay the generation and development of diabetic nephropathy.
【Key words】Diabetic nephropathy ,Urinary albumin excretion rate;Central obesity
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DN是糖尿病常见的慢性并发症之一,在糖尿患者群中的发病率约为20%~40%,伴有终末期肾病(end-stage renal disease,ESRD)的5年生存率小于20%。与糖尿病有关的肾脏病变包括糖尿病性肾小球硬化症、肾小管上皮细胞变性、动脉-微小动脉硬化症