文档介绍：纤溶酶原激活物抑制物
作者:王少波,施秉银,王养维,张新利
【关键词】糖尿病肾病
摘要:目的探讨2型糖尿病患者血浆中的纤溶酶原激活物抑制物1(PAI1)活性水平与2型糖尿病肾病(DN)的关系。方法选取2型糖尿病患者94例,按24 h尿白蛋白排泄率(UAER)分为无DN组(UAER<20 μg/min)、DN微量蛋白尿组(20 μg/min 200 μg/min),选正常对照组26例。分别测定PAI1活性、血糖、血脂、胰岛素水平。结果①2型糖尿病患者血浆PAI1的活性显著高于正常对照组。②血浆PAI1活性在DN患者中升高,且随着DN的加重而呈递增趋势。③DN患者血浆PAI1活性与UAER、胰岛素抵抗指数(HOMEIRI)、空腹胰岛素(FI)、三酰甘油(TG)、体质量指数(BMI)正相关。结论 PAI1升高是DN的危险因素之一。胰岛素抵抗、高三酰甘油血症、肥胖可能是影响PAI1活性的重要因素。
关键词:纤溶酶;原激活物抑制剂1;2型糖尿病;糖尿病肾病
Abstract: Objective To investigate the relationship between plasminogen activator inhibitor1 and diabetic nephropathy. Methods 94 type 2 diabetic patients was divided into diabetes without nephropathy(the urine albumin excretion rate (UAER)<20 μ
g/min),diabetes with microalbuminural (20 μg/min 200 μg/min). The levels of PAI1,serum glucose,serum fasting insulin level and triglyceride were examined in all the diabetic patients and 26 healthy ①The level of PAI1 activity increased in type 2 diabetes pared with controls. ②The level of PAI1 activity significantly increased in the group with diabetic nephropathy,and closely correlated with UAER. ③The level of PAI1 activity was correlated with UAER,homeostasis model assessmentinsulin resistance index (HOMEIRI),serum fasting insulin level (FI),triglyceride (TG) and body weight index (BMI). Conclusion High level of PAI1 activity was a risk of diabetic nephropathy,the insulin res