文档介绍：
小分子化合物诱导胚胎干细胞定向分化的
研究#
孟祥智,周唯,刘艳华,李宗金,范艳**
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(南开大学医学院,天津,300071)
摘要:胚胎干细胞具有无限增殖、自我更新和多向分化的特性,能被诱导分化为所有类型的
细胞。将产生的细胞用于替代治疗具有非常重要的意义。外源性的小分子化合物能够有效诱
导胚胎干细胞的定向分化,并且具有结构简单、易于设计合成、调节作用单一等优点,为胚
胎干细胞的定向分化提供了一个有效的化学工具。本文综述了小分子化合物诱导胚胎干细胞
分化方面的研究。
关键词:胚胎干细胞;小分子化合物;诱导;分化
中图分类号:R313
A chemical approach to inducing differentiation of
embryonic stem cells
Meng Xiangzhi, Zhou Wei, Liu Yanhua, Li Zongjin, Fan Yan
(Medical School of Nankai University, TianJin 300071)
Abstract: Embryonic stem cells (ES) represent potentially unlimited source for all types of
specialized cells and are ideally suited for studies of differentiation and early embryonic
development. They may provide an unlimited cell source for cell replacement therapy. This
requires an improved ability to manipulate stem cell differentiation. Several small molecules have
been recently identified that can be used to selectively control ES cell fate. The development of
chemical approach provides various functional small molecules for stem cell differentiation. In
this review, how small pounds regulate direct differentiation of stem cells is
presented.
Key words: Embryonic stem cell; Small molecule; Induce; Differentiation
0 引言
胚胎干细胞(embryonic stem cells, ES cells)来源于植入前胚胎的内细胞团, 具有自我更
新能力。胚胎干细胞在体外可以无限增殖并保持未分化状态,而且具有多潜能性,在一定条
件下可被诱导分化为成体任何类型组织或器官的细胞(三个胚层的细胞) [1, 2]。
在适当的培养条件下,