阿尔茨海默病神经元细胞周期再进入的研究进展.doc

文档介绍：
阿尔茨海默病神经元细胞周期再进入的研
究进展#
周小英,高旭光**
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(北京大学人民医院神经内科,北京,100044)
摘要:背景:目前阿尔茨海默病(Alzheimer’s Disease, AD)的病理机制学说有 Aβ沉积、
Tau 蛋白磷酸化异常、氧化应激、炎症等假说,但以上任何一种假说都不能解释 AD 的全部
病理特征。研究现状:“神经退行性变——细胞周期”假说打破了过去一直认为“神经元处
于一种有丝分裂后的终末分化状态”的理论,提出在神经退行性变等病理情况下,神经元可
进行分裂增殖,重新进入细胞周期,但这些被迫重新进入细胞周期后的神经元并不能继续分
化,而是走向死亡。AD 中受损神经元重新进入细胞周期已证实为 AD 早期主要病理特征之
一,细胞周期调控异常被证实与 AD 的所有病理特征相关联,且该特征的出现要早于神经原
纤维缠结与老年斑,并持续整个 AD 病程。研究用途:“神经退行性变-细胞周期”假说对
于阐述 AD 病理机制、AD 诊断及治疗均有非常重要的意义。
关键词:阿尔茨海默病;细胞周期;检验点
中图分类号:R741
Research progress about re-entering cell cycle of neurons in
Alzheimer's disease
Zhou Xiaoying1, Gao Xuguang2
(1. Neurology Department, Peking University People's Hospital, Beijing, 100044;
2. Neurology Department, Peking University People's Hospital, 100044)
Abstract: Backgrounds: At present, hypotheses of pathological mechanism of Alzheimer's
disease(AD) include A β deposition, abnormal Tau protein phosphorylation, oxidative stress and
inflammation. But none of above hypotheses can explain all the pathological features of AD.
Current Status: "Neurodegeneration-cell cycle" hypothesis has broken the past theory of "neurons
were in a state of terminal differentiation after mitotic division", which puts forward that neurons
may proliferate and re-enter cell cycle in neurodegeneration and other pathological conditions. But
neurons forced back into cell cycl