文档介绍：:羟丙基。,. 环糊精,,,并进行了红外光谱分析和核磁共振波谱分析;,测定了包合物的稳定常数;以包合率为评价指标优选出p. 环糊精及其四种衍生物与黄芩素包合的最佳工艺,并对包合物迸行了表征,实验结论如下: (1)、、。环糊精、。(2)在相同的条件下,,: >>>>,,。(3)红外光谱法、热重分析法和扫描电镜法共同验证了五种13 .环糊精类物质与黄芩素包合物的生成;以包合率为评价指标,: 黄芩素/:包合温度为50℃,包合时间为90min,:1,搅拌速率为1500 r·min~,%;黄芩素/::l,包合时间为 60min,%,包合温度为50℃,%;黄芩素/:包合温度为40"C,包合时间为90rain,:l,%,%;黄芩素/::l,搅拌速率为1500r·min~,包合温度为40℃,%,%;黄芩素/. 环糊精包合物最佳制备工艺:包合时间为90min,%,包合温度为45℃,:1,%。此五种最佳制备工艺设计合理,稳定可行。、包合物制备工艺及其理化性质的考察,对拓宽黄芩素的应用范围具有重要的意义,能为中药制剂的研究提供帮助。关键词:p一环糊精,衍生物,包合,黄芩素,增溶作用 PRRPARATIoN AND CHARACTERIZATION OF PLEX OF p—CD AND ITS DERIVATIVE WITH BAICALEIN ABSTRACT Inthispaper,four kinds of13-cyclodextrin derivatives were prepa- red:hydroxypropyl-p-cyclodextrin,carboxymethyl—p—cyclodextrin,hydr— oxythyl—p—cyclodextrin and randomly methylated—p— they were identified by IR and solubilization and stable constants of13-cyclodextrin and itsderivatives with baiealein were best inclusion reaction technologies ofp-cyclodextrin and four derivatives with baicalein,using inclusion ration as the evaluation index,were then the inclusions were experimental resultswere asfollows: (1)Four kinds ofp—eyclodextrin derivatives were prepared:hydrox— ,,hydroxythyl—B. cyclodextrin and randomly methylated—p— they were identified by IRandN