文档介绍：学位论文原创性声明本人郑重声明:所呈交的论文是我个人在导师指导下独立进行研究工作取得的研究成果。除了文中特别加以标注引用的内容和致谢的地方外,论文中不包含任何其他个人或集体已经发表或撰写过的研究成果,与我一同工作的同志对本研究所做的任何贡献均已在论文中作了明确的说明并表示了谢意。本论文发表时必须冠名天津医科大学总医院神经外科。学位论文作者签名:旌!日菇≮。旁≥学位论文版权使用授权书本人完全了解天津医科大学有关保留、使用学位论文的规定, 即:学校有权将学位论文的全部或部分内容编入有关数据库进行检索,并采用影印、缩印或扫描等复制手段保存、汇编以供查阅和借阅。同意学校向国家有关部门或机构送交论文,并编入有关数据库。作者签名么丞室!毒师签名:々弛期,_辞占月/,日天津医科大学博士学位论文道具有独特的优势,可以为脑创伤动物模型研究提供一种简便、经济的、可靠的辅助观测方法。借助本研究改进的小动物液压冲击颅脑损伤系统,可以稳定可靠地复制出很多临床常见的创伤性颅脑损伤的动物模型,为创伤性颅脑损伤的深入研究提供优良的动物试验平台。关键词创伤性颅脑损伤动物模型大鼠立体定向控制仪夭漳医科大学博士学位论文 research corrdating witlltr舢atic bmininjury models. Methods: small aIliInalgcereotactic control instnlment:desi昏thc stereotactic fi】【ingequipmem which can fita11directions 锄d call rotate adjustablely,mis instnlment caIl做t11e a11imalstightly and calladjust也e site precisely血it’s wakened state. t11enuid-lection system:improve instnlment which coIlIlects nuid—percussiontr黜atic instmInent aIldsmalla11imals(rat)in血e n11id_percussion traumaticbrain蜘ury model; desi弘conllecting system which hasti曲tco衄ection,call prolong moderate collllection wim litnepressllre attenuation,caIl bee)【llaustcdeasily and can be operated easily. ,ation ofme rol nuid-percussion impact inbrain iI巧ury modeI=92 adlllt rats werc divided缸to two groups: experiment目_oup(n=88)and controlgroup(n=4).Experiment伊oup isdivided into4sub一伊oups,mere are 22 standard opcrating procedure was used inbom experimental group thecon廿01 group we did not made fluid—percussionimpactinjury’也e experiment made t11e ratsimo也ree types oftraumatic braininjury modds:mild,moderate andse、嘲它. The vitalsi弘s and scaleofneumlo西c innuences in behavior were studied in experimental characteristics OfMRI inspect inthegencral sanlples andpam0109y slicewere observed. Result:h ow experiment we havedesi盟ed smallaIlimal ontml mstnlmellt which caIlflt a11directions and iilstnlment can fixtheanimalstighny andadjust t11esiteprecisely in wal(ened