骨髓间充质干细胞分泌因子抑制急性肝衰竭肝细胞HMGB1 的.pdf

文档介绍：® 世界华人消化杂志 2013年7月28日; 21(21): 2009-2015
wcjd@ ISSN 1009-3079 (print) ISSN 2219-2859 (online)
基础研究 BASIC RESEARCH
骨髓间充质干细胞分泌因子抑制急性肝衰竭肝细胞HMGB1
的胞浆移位
雷延昌, 梁青, 罗盼, 肖影群
雷延昌, 梁青, 罗盼, 肖影群, 南昌大学附属感染病医院江西 purified and passaged to 2-3 generations, and the ■背景资料
省南昌市 330006 medium was replaced with DMEM containing 髓间充质干细胞
雷延昌, 主任医师, 主要从事病毒性肝炎肝衰竭免疫发病机制的分泌因子(mesen-
研究. % fetal bovine serum. After further culture chymal stem cell-
国家自然科学基金资助项目, No. 81160065 for 24 h, the medium containing MSC-CM was derived molecules,
江西省科技支撑基金资助项目, No. 2009JX0096 obtained. Thirty-six healthy Balb/c mice were MSC-CM)可以逆
南昌市科技局重点基金资助项目, No. 洪财政[2012]37号社转小鼠急性肝功
会发展支撑计划-10 randomly divided into two groups: an acute liver
能衰竭, 后期炎症
课题设计由雷延昌主持; 研究过程由梁青、罗
作者贡献分布: failure group (control group) and a MSC-CM treat- 因子高迁移率族
盼、肖影群及雷延昌实施; 论文写作由雷延昌与罗盼完成.
ment group. The Kaplan-Meier method was used 蛋白B1(high mo-
通讯作者: 雷延昌, 主任医师, 330006, 江西省南昌市洪都中大
道167号, 南昌大学附属感染病医院. ycleihust@ for survival analysis. Serum ALT/AST levels were bility group box 1,
电话: [phone] measured at different time points, and liver tissue HMGB1)及其肝
收稿日期: 2013-05-26 修回日期:2013-06-24 pathological examination was performed. Serum 细胞内移位在急
接受日期: 2013-07-03 在线出版日期: 2013-07-28 性肝衰竭的发生
levels of HMGB1, interleukin-1β(IL-1β), tumor 中有重要作用. 然
necrosis factor-α(TNF-α), IL-6 and IL-10 were de- 而, MSC-CM治疗
tected by