文档介绍:江西中医药大学学报 2021 年 8 月第 33 卷第 4 期
JOURNAL OF JIANGXI UNIVERSITY OF TCM 2021 Vol. 33
…of…cinobufagin.…Results:…Data…analysis…showed…that…there…were…30…
active…ingredients,…7…potential…protein…targets…and…15…KEGG…pathways…related…to…cancer.…Cinobufotalin…acts…on…target…proteins…such…as…BAX,…
BID,…CASP9…and…FAS.…Among…them,…6…protein…targets…act…on…p53…signaling…pathway,…6…protein…targets…act…on…cancer…signaling…pathway,…and…
3…protein…targets…act…on…colorectal…cancer…signaling…pathway.…Conclusions: Cinobufotalin…plays…an…important…role…in…colorectal…cancer,…non-
small…cell…lung…cancer,…prostate…cancer,…tumor…suppressor…pathway…and…tumor…necrosis…factor…pathway.…This…study…provides…a…theoretical…basis…
for…the…targeting…therapy,…pharmacological…research…and…clinical…application…of…traditional…Chinese…medicine…in…cancer.
[Key words] Network…Pharmacology;Cinobufagin;Anti-cancer;Mechanism…of…Action
华蟾素(Cinobufotalin)为我国传统中药中华 华本草》记载:蟾蜍“味辛、性凉,有毒。归心、肝、
大蟾蜍或黑眶蟾蜍等干皮提炼出的有效成分。蟾 脾、肺经”,能“解毒散结,消积利水,杀虫消疳。
蜍作为药物治疗疾病由来已久,其药性理论记载, 主治痈疽、疗疮、发背、瘰疬、恶疮、癥瘕癖积、臌
首见于我国第一部药物学专著《神农本草经》“蝦 胀、水肿、小儿疳积、破伤风、慢性咳喘”,并进一
蟆,味辛、寒,主邪气,破癥坚血,痈肿,阴疮,服