【医学--外文文献--肿瘤与治疗】RapidArc planning and delivery in patients with locally advanced head-and-neck cancer undergoing chemoradiotherapy.pdf

文档介绍：Int. J. Radiation Oncology Biol. Phys., Vol. 79, No. 2, pp. 429–435, 2011
Copyright Ó 2011 Elsevier Inc.
Printed in the USA. All rights reserved
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doi:.
CLINICAL INVESTIGATION Head and Neck
RAPIDARC PLANNING AND DELIVERY IN PATIENTS WITH
LOCALLY ADVANCED HEAD-AND-NECK CANCER
UNDERGOING CHEMORADIOTHERAPY
PATRICIA DOORNAERT, .,* WILKO F. A. R. VERBAKEL,.,* MICHAEL BIEKER, ., .,*
BEN J. SLOTMAN, ., .,* AND SURESH SENAN,., ., .*
From the *Department of Radiation Oncology, VU University Medical Center, Amsterdam, herlands
Purpose: Volumetric modulated arc therapy (RapidArc, Varian Medical Systems) permits the delivery of highly
conformal dose distributions. We studied planning and delivery in patients who underwent RapidArc for locally
advanced head-and-neck cancer (HNC).
Methods and Materials: A total of 35 consecutive patients pleted RapidArc with concurrent chemother-
apy for Stages III-IV tumors of the oro- and hypopharynx/larynx in our center were identified. All underwent
bilateral neck irradiation and 21 patients had at least N2 disease. A simultaneous integrated boost (SIB) delivered
70 Gy (in 2 Gy/fraction) to the planning target volume (PTV)boost and elective nodal regions (PTVelect) received
Gy. A standard planning constraint set was used