文档介绍：新药研发前沿
基础医学与法医学院
药理教研室
张媛媛
四川大学专业选修课程
2
药物发展史上最大的悲剧——反应停
3
4月24日世界实验动物日
4
Year
Scientist(s)
Animal(s)
Contributions Made
2007
hi*, Evans, Smithies
Mouse
Discovery of principles for introducing specific gene modifications in mice by the use of embryonic stem cells
2006
Fire, Mello
Roundworm
RNA interference, or gene silencing by double-stranded RNA
2005
Marshall, Warren
Gerbil
Discovery of a bacterium that leads to gastritis and peptic ulcer disease
2004
Axel, Buck
Mouse
Odorant receptors and anization of the olfactory system
2003
Lauterbur, Mansfield
Clam, rat
Imaging of human ans with exact and non-invasive methods (MRI)
2002
Brenner, Horvitz, Sulston
Roundworm
ic regulation an development and programmed cell death
2000
Carlsson, Greengard, Kandel
Mouse, Guinea pig, sea slug
Signal transduction in the nervous system
1999
Blobel
Various animal cells
Proteins have intrinsic signals that govern their transport and localization in the cell.
1998
Furchgott, Ignarro, Murad
Rabbit
Nitric oxide as signaling molecule in cardiovascular system
1997
Prusiner*
Hamster, mouse
Discovery and characterization of prions
1996
Doherty, Zinkernagel
Mouse
Immune-system detection of virus-infected cells
1995
Lewis, Wieschaus, Nusslein-Volhard
Fruit fly
ic control of early structural development
1992
Fischer, Krebs
Rabbit
Regulatory mechanism in cells
1991
Neher, Sakmann
Frog
munication between cells
1990
Murray*, Thomas*
Dog
Organ transplantation techniques
1989
Varmus, Bishop
Chicken
Cellular origin of retroviral oncogenes
1987
Tonegawa
Mouse
Basic principles of antibody synthesis
1986
Levi-Montalcini, Cohen
Mouse, chick, snake
Nerve growth factor and epidermal growth factor
1984
Milstein, Kohler, Jerne
Mouse
Techniques of monoclonal antibody formation
1982
Bergstrom, Samuelsson, Vane
Ram, rabbit, guinea pig
Discovery of prostaglandins
1981
Sperry, Hubel*, Wiesel*
Cat, monkey
Processing of vis