文档介绍：针刺治疗急性期贝尔麻痹有效性与安全性的系统评价
陈璐1 ,李素荷1,曾侠一2
(,广州 510405;,广州 510115)
摘要:目的:对针刺治疗急性期贝尔麻痹临床随机对照试验进行方法学质量评价及有效性、安全性评价,了解针刺治疗急性期贝尔麻痹的现状、临床疗效的真实程度及可应用性。方法:电子检索PubMed、Cochrane图书馆、EMBASE、KI、VIP数据库,手工检索广州中医药大学图书馆期刊资料库,根据纳入和排除标准,筛选出符合纳入标准的针刺治疗急性期贝尔麻痹随机对照试验,用Cochrane reviews handbook ,疗效评价采用Review 。结果:最终纳入17项研究,共1564例患者,以痊愈率作为主要结局指标,Meta分析结果显示:①急性期针刺与西药比较尚无差异(P=>)。②急性期针刺结合西药优于单纯西药治疗(RR=,95%CI(,),Z=,P=<)。③急性期针刺治疗优于单纯TDP照射(RR=,95%CI(,),Z=,P=<)。④不良反应:17项研究均未提及治疗组和对照组不良反应。结论:针刺作为安全、有效的治疗手段,适宜在贝尔麻痹急性期介入,同时配合常规西药治疗以提高临床疗效。但纳入的研究质量不高,尚需更多高质量的随机对照试验来进一步证实,为临床决策提供可靠的依据。
关键词:针刺;随机对照试验;贝尔麻痹急性期;系统评价
Systematic evaluation of therapeutic effect and safety for acupuncture treatment of Acute Bell’s facial paralysis
CHEN Lu1 , LI Su-he1 ,ZENG Xia-yi 2 ( University of TCM, Guangzhou 510405, China; 2. Guangzhou YueXiu District Children's Hospital, Guangzhou 510115)
Abstract: Objective: To access the therapeutic effect and safety of acupuncture on acute Bell’s facial paralysis. Methods: All relevant randomized controlled trials for acupuncture treatment of acute Bell’s facial paralysis are from PudMed , The Cochrane Library , EMBASE , CBM , CNKI , VIP and so on. According to Cochrane systematic assessment method of evidence base Medicine, made the Meta analysis on RCT for acupuncture treatment of the acute Bell’s facial paralysis. The date was statistically analyzed with the special software RevMan . Result: 17 paper of RCT including 1564 patients met the enrolled criteria. Meta-analysis included that acupuncture treatment of acute Bell’s paralysis have no obvious difference from the hormone group(P=>).But the bined with western medicine group was better than the western medicine group(RR=,95%CI(,),Z=,P=<).And the acupuncture treatment group was better than the TDP group(RR=,95%CI(,),Z=,P=<).Conclusion: Acupuncture bin