文档介绍：32
食品与药品
Food and Drug
2012年第 14卷第 01期
不同剂量葡萄籽提取物抗氧化能力的人群试验
丰佃娟1, 徐贵发2, 赵妍1
(1. 山东大学齐鲁医院营养科,山东济南 250012;2. 山东大学公共卫生学院营养与食品卫生研究所,山东
济南 250012)
摘要:目的研究不同剂量的葡萄籽提取物软胶囊对人体抗氧化能力的影响。方法选择60~65岁的健康志愿者28人,随
机分为对照组和低、中、高3个剂量组,每组7人,对照组采用空白对照。3个剂量组受试者每天口服相当于原花青素50,
100,150 mg的葡萄籽提取物软胶囊,连续服用1个月。试验前后各测1次血清超氧化物歧化酶(superoxide dismutase,
SOD)、谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-Px)活性和丙二醛(maleic dialdehyde,MDA)含量。结果
高剂量组SOD 活性较试验前升高(P<);中、高剂量组GSH-Px活性均高于试验前(P<,P<),高剂量组高
于对照组(P<);中、高剂量组MDA含量均低于试验前(P<,P<),且低于对照组(P<,P<)。
结论服用葡萄籽提取物软胶囊1个月后,中、高剂量组(100,150 mg)具有显著的抗氧化作用。
关键词:葡萄籽提取物;原花青素;抗氧化
中图分类号:
文献标识码:A
文章编号:1672-979X(2012)01-0032-03
Anti-oxidative Effect of Different Dose of Grape Seed Extract in Human Body
FENG Dian-juan1, XU Gui-fa2, ZHAO Yan1
(1. Department of Nutriology, Qilu Hospital of Shandong University, Jinan 250012, China; 2. Institute of Nutrition
and Food Hygiene, School of Public Health, Shandong University, Jinan 250012, China)
Abstract: Objective To study the anti-oxidative effect of different dose of grape seed extract soft capsule in human
body. Methods Twenty-eight healthy volunteers aging from 60 to 65 were randomly divided into four groups: control
group and low dose, middle dose, high dose group. Seven volunteers were in each group. The control group was
given nothing. Each dose group was given grape see