文档介绍：新生儿寒冷损伤综合征 Neonatal cold injury syndrome
Department of pediatrics
陈平洋
第七章第十三节
中南大学儿科学教研室
目的要求
To be familiar with etiology、 mechanism and prevention
To master the clinical manifestation and treatment
summary(概述)
Neonatal cold injury is a disorder, which is due to coldness(寒冷) , premature birth(早产) , infection(感染) and asphyxia(窒息).
The clinical manifestations are hypothermia(低温) associated with lethargy(嗜睡), edema(水肿) and sclerema(硬化) of the skin, and some degree of an injury.
Etiology and Mechanism
1.   Intrinsic factors(内因)
1) 温度调节中枢(thermotaxic center )
发育不成熟
2) 散热过多( excessive heat loss )
3) 产热不足,以棕色脂肪( brown fat )的化
学产热方式为主,缺乏寒颤等物理产热方式
4) 饱和脂肪酸( saturated fatty acid )含量多,
熔点高。
2. Extrinsic factors(外因)
1) 寒冷(coldness)
2) 摄入不足(intake deficiency)
3) 早产(premature birth)
4) 疾病(diseases)
①感染( infection)
②窒息( asphyxia )
Clinical Manifestation
1、General manifestation(一般情况)
  decreased activity(少动), feeble cry(少
哭), poor feeding(少吃),
low temperature(低体温)
2、Skin feature(皮肤表现)
1)cold, bright red, edema and sclerema
(硬化)
2)gradation(顺序)
calf (小腿) thigh(大腿) Buttock
(臀部) Face(面部) upper limb
(上肢) Total body(全身)
3)Grades of severity (分度)
According to an area of sclerema
mild(轻度): <20%
moderate(中度): 20% ~ 50%
severe(重度): >50%
3、多器官功能损伤
circulatory collapse(循环衰竭)
acute renal failure(急性肾功能衰竭)
pulmonary hemorrhage(肺出血)
respiratory failure (呼吸衰竭)
Pulmonary hemorrhage(肺出血)
Treatment
⒈ rewarming(复温)
① body temperature 〉30 ℃
将患儿置于中性温度(neutral temperature)
的温箱中,于 6 ~ 12hr恢复体温。
② body temperature〈30 ℃
将患儿置于比肛温高1~2 ℃的温箱中,待肛
温恢复至35 ℃时,维持箱温的温度于中性
温度。